Question 1

What are the signaling pathways by which CCR2+  monocytes and dendritic cells regulate cardiac fibroblast activation and differentiation?

Work Package (WP)1 will identify signals that regulate CCR2+ macrophages and dendritic cell differentiation. WP2 will define effector molecules whereby CCR2+ cells promote fibrosis. Top left: single cell RNA sequence of cardiac myeloid cells.
Work Package (WP)1 will identify signals that regulate CCR2+ macrophages and dendritic cell differentiation. WP2 will define effector molecules whereby CCR2+ cells promote fibrosis. Top left: single cell RNA sequence of cardiac myeloid cells.

Network Members

Florian Leuschner, MD

Florian Leuschner, MD

Heidelberg University, Lead Coordinator – Question 1

Kory Lavine, MD, PhD

Kory Lavine, MD, PhD

Washington University School of Medicine, Senior Investigator – Question 1

Andrew Koenig, PhD

Andrew Koenig, PhD

Washington University School of Medicine, Early Career Investigator – Question 1

Andrea Bredemeyer, PhD

Andrea Bredemeyer, PhD

Washington University School of Medicine, Early Career Investigator – Question 1

Oleksandr Dmytrenko, BA

Oleksandr Dmytrenko, BA

Washington University School of Medicine, Early Career Investigator – Question 1

Laura Wienecke, MD

Laura Wienecke, MD

Heidelberg University, Early Career Investigator – Question 1

Sören Meyer

Sören Meyer

Heidelberg University, Early Career Investigator – Question 1

Florian Sicklinger, MD

Florian Sicklinger, MD

Heidelberg University, Early Career Investigator – Question 1