Question 1

What are the signaling pathways by which CCR2+  monocytes and dendritic cells regulate cardiac fibroblast activation and differentiation?

Work Package (WP)1 will identify signals that regulate CCR2+ macrophages and dendritic cell differentiation. WP2 will define effector molecules whereby CCR2+ cells promote fibrosis. Top left: single cell RNA sequence of cardiac myeloid cells.
Work Package (WP)1 will identify signals that regulate CCR2+ macrophages and dendritic cell differentiation. WP2 will define effector molecules whereby CCR2+ cells promote fibrosis. Top left: single cell RNA sequence of cardiac myeloid cells.

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