What are the signaling pathways by which CCR2+ monocytes and dendritic cells regulate cardiac fibroblast activation and differentiation?
![Work Package (WP)1 will identify signals that regulate CCR2+ macrophages and dendritic cell differentiation. WP2 will define effector molecules whereby CCR2+ cells promote fibrosis. Top left: single cell RNA sequence of cardiac myeloid cells.](https://immunofibhf.wustl.edu/files/2021/10/question-1-figure-1024x472.png)
Network Members
![Florian Leuschner, MD](https://immunofibhf.wustl.edu/files/2021/10/leuschner_florian-klinik-280x386.jpeg)
Florian Leuschner, MD
Heidelberg University, Lead Coordinator – Question 1
- Phone: 06 221 56-8611
- Email: florian.leuschner@med.uni-heidelberg.de
![Kory Lavine, MD, PhD](https://immunofibhf.wustl.edu/files/2021/10/LavineK_300-280x386.jpg)
Kory Lavine, MD, PhD
Washington University School of Medicine, Senior Investigator – Question 1
- Phone: 314.362.1171
- Email: klavine@wustl.edu
![Andrea Bredemeyer, PhD](https://immunofibhf.wustl.edu/files/2021/10/Andrea-Bredemeyer-280x386.jpg)
Andrea Bredemeyer, PhD
Washington University School of Medicine, Early Career Investigator – Question 1
![Oleksandr Dmytrenko, BA](https://immunofibhf.wustl.edu/files/2021/10/Oleksandr-Dmytrenko-280x386.jpg)
Oleksandr Dmytrenko, BA
Washington University School of Medicine, Early Career Investigator – Question 1